DITHIOCARBAZATE AND YOUR METAL COMPLEXES AS TRYPANOCIDAL ACTIVITY

  • Zumira Aparecida Carneiro Universidade de São Paulo, Ribeirão Preto.
  • Andressa R. Rettondin Universidade Federal Triângulo Mineiro
  • Ana C. R. Gonalves Universidade Federal Triângulo Mineiro
  • Pedro Ivo Maia Universidade Federal Triângulo Mineiro
  • Sérgio Albuquerque Universidade de São paulo

Resumo

American Trypanosomiasis or Chagas disease is endemic in Latin America. Chagas disease is caused by the parasite T. cruzi. According to the World Health Organization (WHO), 12 million people are infected with the T. cruzi, resulting in an annual death toll of 50,000. The pharmacotherapy developed many decades ago is ineffective in most patients and has serious side effects. There is also a lack of interest from pharmaceutical companies in the development and production of new such drugs. Here we report gold(III) complexes exhibits high in vivo trypanocidal activity when compared to benznidazole®. The present work reports in vivo trypanocidal activity in a murine model (The Animal Ethics Committee - nº 15.1.713.60.7.) of acute of Chagas disease. The mice were infected with Y strain trypomastigote forms of T. cruzi and distinct groups were treated with benznidazole®, or gold(III) complexes, at the same concentration. After treatment, the parasitemia was evaluated and the mortality curve and PCR analysis were performed. This work revealed that gold(III) complexes was effective in reducing the parasitemia of mice treated with a concentration 20 times lower than the concentration normally used in the treatment benznidazole (Clinically used at a concentration of 100 mg. Kg-1. day-1). In addition, gold(III) complexes was effective in reducing liver and heart inflammation infected mice. The gold(III) complexes, therefore, presented as a potent trypanocidal agent.

Biografia do Autor

Zumira Aparecida Carneiro, Universidade de São Paulo, Ribeirão Preto.
Departamento de Análises Clínicas Toxicológicas e Bromatológicas. Avenida do Café, s/n - Laboratório de ParasitologiaMonte Alegre14040-903 - Ribeirao Preto, SP - Brasil
Sérgio Albuquerque, Universidade de São paulo
Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto – FCFRP-USP, Universidade de São Paulo
Publicado
2016-10-17
Seção
FOTOS - ENCONTRO NACIONAL DE PATOLOGIA CLÍNICA VETERINÁRIA 2017