HYPOXIA-MEDIATED INVASIVENESS AND METASTASIS: FOCUS ON CANINE AND HUMAN MAMMARY TUMORS

Raphael Simões Vieira, Sofia Borin-Crivellenti

Resumo


Breast cancer and canine mammary cancer are malignancies that affect millions of bitches and women in the world. Several studies show a worst prognosis for patients with hypoxic mammary tumor (tumors with low oxygen perfusion) due to an increased expression of Hypoxia Inducible Factor (HIF) and consequently several other hypoxia-induced molecules, like Vascular Endothelial Growth Factor (VEGF), Lysyl-oxidase (LOX) and Erythropoietin (EPO). All these molecules and factors contribute to a higher chance of tumor cells survival in this hypoxic microenvironment. In this paper review, molecular mechanisms which hypoxia influences on breast cancer were covered for both women and bitches, with some promising drugs that could target these molecules and increase patient survival and quality of life.


Palavras-chave


Canine mammary tumor; hypoxia-inducible factor; HIF; VEGF; LOX.

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DOI: http://dx.doi.org/10.26843/investigacaov1732018p%25p