RED WINE, GRAPE JUICE OR RESVERATROL CONSUMPTION EFFECTS ON LIPID AND GLYCEMIC PROFILE AND HEPATIC MORPHOLOGY OF WISTAR RATS SUBMITTED TO HIGH FAT DIET AND PHYSICAL TRAINING

Nina da Matta Alvarez Pimenta, Raiza da Silva Ferreira-Fiochi, Leticia Monteiro da Fonseca Cardoso, Bruna Ferreira Mota, Isabelle Waleska Santos de Medeiros Silva, Juliana Arruda de Souza Monnerat, Renata Beatriz da Rocha Ramalho, Cristiane Correira Teixeira, Vilma Blondet Azeredo, Gilson Teles Boaventura, Mauricio Alves Chagas, Gabrielle de Souza Rocha, Sergio Girão Barroso

Resumo


The aim of this study was to evaluate the effects of red wine, grape juice or resveratrol consumption on lipid and glycemic profile and liver nuclear area and circularity of Wistar rats submitted to the high fat diet and physical training. Wistar rats, with 90 days, were divided into 5 groups: Control (GC); High Fat (HFG); Grape Juice (GJG); Red Wine (WG) and Resveratrol (RG). The animals performed a running protocol. After 60 days, the animals were anesthetized, blood was collected for biochemical analyzes, sacrificed and the liver removed. Liver samples were mounted on histological slides and stained with hematoxylin and eosin. The results were expressed as mean ± standard deviation and assessed for normality with Kolgomorov-smirnov test. One way ANOVA, and Bonferroni post-test were used. It was considered significant when p <0.05, using PRISMA 5.0 software. Groups consuming high fat diet had a significantly higher energetic intake compared to CG, however, there was no significant difference in body mass and weight gain among groups. There was no significant difference in glucose and triglyceride levels among groups. Total cholesterol and high density lipoprotein (HDL) were higher in GJG when compared to the other groups. Hepatocytes nuclear areas were significantly higher in the HFT and WG, with no difference in nucleus circularity among groups. It was concluded that grape juice showed better results in biochemical analysis and the resveratrol solution presented better results in liver morphology.


Palavras-chave


polyphenols, wine, grape juice, resveratrol, liver

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DOI: http://dx.doi.org/10.26843/investigacao.v16i8.2393